Six research projects at Queen’s have received funding from the New Frontiers in Research Fund’s (NFRF) 2020 Exploration competition, a program that encourages scholars to take risks, and that fosters discoveries and innovations that could have significant impacts on our world.
Tumours that arise throughout the body called neuroendocrine neoplasms (NENs) cause metastatic disease in up to 50 per cent of patients, giving those diagnosed months to years to survive. However, the molecular basis of highly variable clinical outcomes is poorly understood. Neil Renwick (Pathology and Molecular Medicine), Kathrin Tyryshkin (School of Computing) and collaborators have proposed a radical new way to investigate NENs. The researchers propose using graph neural network models, typically used in computer science, to investigate the gene networks that drive or mediate tumor aggressiveness. The understanding of these molecular social networks may improve accurate knowledge of tumour behaviour and even treatment response, improving NEN clinical outcomes.
Queen’s researchers will receive $1.5 million ($250,000 per project) from the fund to advance interdisciplinary projects with multiple partners and collaborators. Nationally, the NFRF competition will provide $14.5 million in grants to researchers across Canada, funding 117 projects.
Pharmaceuticals have become contaminants of emerging concern through increased presence in the environment through wastewater, causing great risk to ecosystems and human health. A contributor to this issue is wastewater treatment facilities that are unable to eliminate pharmaceutical ingredients and excreted drug metabolites through their operating systems. Bas Vriens (Geological Sciences and Geological Engineering) and Martin Petkovich (Biomedical and Molecular Sciences) aim to develop new technology that will act as a 'mega-liver', filtering out harmful pharmaceuticals in wastewater treatment facilities in a cost-efficient way to help ensure good health for our communities and environment.