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<li> <a href="/articles/news">News</a> <span class=""> / </span> </li> <li> </li> <li> Cancer Research Publication </li> <li></li> </ol> </nav> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div role="main" class="main main-page"> <div class="clearfix"></div> <div class="clearfix"></div> <div class="clearfix"></div> <div id="content" class="content content-full"> <div class="container"> <div class="content-main-inner"> <div class="row"> <div id="page-main-content" class="main-content col-xs-12 col-md-8 sb-r "> <div class="main-content-inner"> <div class="content-main"> <div class="region region-content"> <div id="block-gavias-financial-content" class="block block-system block-system-main-block no-title"> <div class="content block-content"> <!-- Start Display article for teaser page --> <!-- Start Display article for detail page --> <article data-history-node-id="1187" about="/articles/news/cancer-research-publication" typeof="schema:Article" class="node node-detail node--type-article node--promoted node--view-mode-full clearfix"> <div class="post-block"> <div class="post-thumbnail post-standard"> <div class="field field--name-field-image field--type-image field--label-hidden field__item"> <div class="item"> <img property="schema:image" loading="lazy" src="/sites/pathology/files/styles/announcements/public/articles/Cancer%20Research%20Publication_2025-10-10_2.png?itok=64bMthgP" alt="Cancer Research Publication" typeof="foaf:Image" class="image-style-announcements" /> </div> </div> </div> <div class="post-content"> <h1 class="post-title"><span property="schema:name" class="field field--name-title field--type-string field--label-hidden">Cancer Research Publication</span> </h1> <span property="schema:name" content="Cancer Research Publication" class="rdf-meta hidden"></span> <span property="schema:interactionCount" content="UserComments:0" class="rdf-meta hidden"></span> <div class="post-meta"> <span class="post-categories"> <div class="field field--name-field-post-category field--type-entity-reference field--label-hidden field__item"><a href="/articles/news" hreflang="en">News</a></div> </span> | <span class="post-created"> 10 October 2025 </span> </div> </div> <div class="node__content clearfix"> <div property="schema:text" class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span><span><span><span>Congratulations to Brian Laight, Danielle Harper, Natasha Dmytryk and Connie Zhang for their ground- breaking </span></span></span></span><span><span><span><span><em>Cancer Research </em></span></span></span></span><span><span><span><span>paper showing that the FES protein tyrosine kinase plays an immune checkpoint role in antigen presenting cells which makes it a potential therapeutic target to enhance the efficacy of immune checkpoint inhibitors like anti-PD1 which work on the T cells.</span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span>Brian assembled an impressive team of collaborators from within and beyond the lab to support his findings using genetic mouse engraftment models. </span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span>Brian has returned to medical school to continue his progress through the MD-PhD program. Connie has moved on to a position in industry, Natasha has entered medical school, and Dani is in the last stages of her PhD with plans to purse a PDF in the UK. This research project is continuing with new MSc student Julian Simonetti and research associates Yan Gao and Changnian Shi, with engagement by two eager undergraduate students Alisha Varty-Higgs and Steph Trandafir.</span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span>This work was supported by grants from the CIHR and the Canadian Cancer Society. Read their published work here: </span><a href="https://aacrjournals.org/cancerres/article/85/14/2643/763441/Fes-Deficient-Macrophages-Prime-CD8-T-Cells-to">Fes-Deficient Macrophages Prime CD8+ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy | Cancer Research | American Association for Cancer Research</a>.</span></span></span></span></span></span></span></span></p> </div> </div> <div id="node-single-comment"> </div> </div> </article> <!-- End Display article for detail page --> </div> </div> </div> </div> </div> </div> <!-- Sidebar Left --> <!-- End Sidebar Left --> <!-- Sidebar Right --> <div class="col-lg-4 col-md-4 col-sm-12 col-xs-12 sidebar sidebar-right theiaStickySidebar"> <div class="sidebar-inner"> <div class="region region-sidebar-right"> <div class="views-element-container block block-views block-views-blockpost-other-block-1" id="block-gavias-financial-views-block-post-other-block-1"> <h2 class="block-title" ><span>Recent Posts</span></h2> <div 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