Tuesday November 5th, 2024
4:00 – 5:00pm: Lecture in Richardson Amphitheatre Rm. 104 or Zoom
5:00pm: Reception in Richardson Lab Rm.101
Dr. Peter Greer
Professor & Stauffer Chair
Pathology & Molecular Medicine
Queen’s University
An unexpected twist in the ongoing story of the FES proto-oncogene
FES was one of the first retroviral oncogenes discovered, from tumors in cats and chickens. It was expected that it would turn out play a cancer cell intrinsic role in human tumors. However, that’s not the way the story has evolved.
This talk will provide an historical account of the discovery of the FES viral oncogene and cellular proto-oncogene, subsequent work revealing the structure and function of the encoded protein tyrosine kinase, and more recent evidence that its ability to contribute to cancer may involve and unexpected role in regulating immune cells, not cancer cells.